Journey from disease to drug discovery
Discover how modern medicine was built. This podcast explores the careful, often overlooked history of how doctors and scientists identified diseases, uncovered their secrets in the lab, and developed treatments that transformed lives. Join us to appreciate the work behind the medicines we rely on today.
Journey from disease to drug discovery
Discover how modern medicine was built. This podcast explores the careful, often overlooked history of how doctors and scientists identified diseases, uncovered their secrets in the lab, and developed treatments that transformed lives. Join us to appreciate the work behind the medicines we rely on today.
LATEST EPISODE
JUNE 30, 2025
Encephalitis, T Cells, and a Cytokine Surprise
In this episode, we trace a compelling scientific journey—from a murine model of post-measles encephalopathy that challenged conventional views of T cell biology, to the eventual identification of the IL-23/17 axis as a critical driver of autoimmune inflammation.
Adam J. Brown, MD
Rheumatologic and Immunologic Disease
Cleveland Clinic
LISTEN
LATEST EPISODE
JUNE 30, 2025
Encephalitis, T Cells, and a Cytokine Surprise
In this episode, we trace a compelling scientific journey from a murine model of post-measles encephalopathy that challenged conventional views of T cell biology, to the eventual identification of the IL-23/17 axis as a critical driver of autoimmune inflammation.
Adam J. Brown, MD
Rheumatologic and Immunologic Disease
Cleveland Clinic
LISTEN
Recent episodes
May 20, 2025
Dr. Adam J. Brown explores the history of polymyalgia rheumatica (PMR), from its early descriptions to its formal naming in the 1950s. He highlights its close link to giant cell arteritis (GCA), supported by decades of clinical and imaging studies, and reflects on how evolving technology has deepened our understanding of these interconnected conditions.
LISTEN
April 28, 2025
Dr. Adam J. Brown and Dr. Joseph Parambil wrap up their series on pulmonary hypertension by focusing on treatment strategies and medication options, especially in scleroderma patients. They discuss functional assessments, vasoreactivity testing, and emerging therapies targeting the TGF-beta pathway.
LISTEN
April 13, 2025
Explore the early therapies and evolving vascular physiology that transformed the treatment of pulmonary hypertension. Learn about key breakthroughs like prostacyclin, endothelin antagonists, and nitric oxide, and how discoveries in nerve-vessel interactions reshaped our understanding of the disease. This episode highlights the scientific journey from basic physiology to targeted therapies that now define modern care.
LISTEN
April 1, 2025
Delve into the history of pulmonary hypertension, tracing its recognition from the late 19th century to the modern era. Explore key milestones, such as the 1965 aminorex epidemic and the 1980s toxic oil syndrome in Spain. This episode highlights how early discoveries, including bizarre case studies and global health events, laid the groundwork for today’s understanding of this complex disease.
LISTEN
Recent episodes
History of polymyalgia rheumatica: The origin of the pain & link to giant cell arteritis
Dr. Adam J. Brown explores the history of polymyalgia rheumatica (PMR), from its early descriptions to its formal naming in the 1950s. He highlights its close link to giant cell arteritis (GCA), supported by decades of clinical and imaging studies, and reflects on how evolving technology has deepened our understanding of these interconnected conditions.
May 20, 2025
LISTEN
Pulmonary hypertension, part 4: The therapeutics, with Dr. Joseph Parambil
Dr. Adam J. Brown and Dr. Joseph Parambil wrap up their series on pulmonary hypertension by focusing on treatment strategies and medication options, especially in scleroderma patients. They discuss functional assessments, vasoreactivity testing, and emerging therapies targeting the TGF-beta pathway.
April 28, 2025
LISTEN
Pulmonary hypertension, part 3: Early therapies and vascular physiology
Explore the early therapies and evolving vascular physiology that transformed the treatment of pulmonary hypertension. Learn about key breakthroughs like prostacyclin, endothelin antagonists, and nitric oxide, and how discoveries in nerve-vessel interactions reshaped our understanding of the disease. This episode highlights the scientific journey from basic physiology to targeted therapies that now define modern care.
April 13, 2025
LISTEN
Pulmonary hypertension and the rheumatologist, part 2: The history
Delve into the history of pulmonary hypertension, tracing its recognition from the late 19th century to the modern era. Explore key milestones, such as the 1965 aminorex epidemic and the 1980s toxic oil syndrome in Spain. This episode highlights how early discoveries, including bizarre case studies and global health events, laid the groundwork for today’s understanding of this complex disease.
April 1, 2025
LISTEN
An array of resources
Our comprehensive suite of professional services caters to a diverse clientele, ranging from homeowners to commercial developers.
- Collaborate with fellow architects.
- Showcase your projects.
- Experience the world of architecture.
Études Newsletter
- A world of thought-provoking articles.
- Case studies that celebrate architecture.
- Exclusive access to design insights.